Rabbit Polyclonal Antibody to Tau(Phospho-Ser404)
货号:
P40110
别名:
MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
应用:
WB,IHC,IF
反应种属:
Human,Mouse,Rat
抗体类型:
Primary antibody
Swissprot:
P10636
规格:
目录价
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Description |
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Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
References |
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Li G, Yin H, et.al .(2004) J Biol Chem ; 279(16): 15938-45. Noble W, et al. (2003) Neuron ; 38(4): 555-65. Giasson BI, et al.(2002). Biochemistry; 41(51): 15376-87. Lee G., et.al. (1989). Neuron 2:1615-1624. Andreadis A.et.al. (1992) Biochemistry 31:10626-10633. |
Specification |
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Aliases | MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau |
Entrez GeneID | 4137; |
Swissprot | P10636 |
WB Predicted band size | 48 62 78 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | Peptide sequence around phosphorylation site of serine 404 (D-T-S(p)-P-R) derived from Human Tau. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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WB | 1/500-1/1000 |
IHC | 1/50-1/100 |
IF | 1/100-1/200 |
Product Image
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Western blot analysis of extracts from C6 cells, treated with calf intestinal phosphatase (CIP), using Tau (Phospho-Ser404) Antibody P40110.
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Western blot analysis of extracts from C6 cells using Tau(Phospho-Ser404) Antibody P40110.
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Immunofluorescence staining of methanol-fixed Hela cells using Tau(Phospho-Ser404) Antibody P40110.
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Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer