Rabbit Polyclonal Antibody to SMC1(Phospho-Ser957)
货号：
P40187
别名：
SM1A; SMC1A; SMC1L1; SMC1 alpha protein;
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q14683
规格：
目录价
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Description |
|---|
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. |
References |
|---|
| Yang XM. et al. (2004) Mol Cell Biol. 24(12): 5290-5303.Kim ST. et al. (2002) Genes Dev. 16(5): 560-570.Revenkova E.et al. (2001) Mol Cell Biol. 21(20): 6984-6998 |
Specification |
|
|---|---|
| Aliases | SM1A; SMC1A; SMC1L1; SMC1 alpha protein; |
| Entrez GeneID | 8243; |
| Swissprot | Q14683 |
| WB Predicted band size | 145kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of serine 957 (G-S-S(p)-Q-G) derived from Human SMC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from 293 cells untreated or treated with UV using SMC1(Phospho-Ser957) Antibody P40187.
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Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using SMC1(Phospho-Ser957) Antibody P40187(left) or the same antibody preincubated with blocking peptide(right).
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