Rabbit Polyclonal Antibody to p62Dok(phospho-Tyr398)
货号：
P40254
别名：
DOK1
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q99704
规格：
目录价
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Description |
|---|
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
References |
|---|
| Michael J. Wick, et al. (2001) J. Biol. Chem ; 276: 42843 - 42850.Paul D. Simoncic, et al. (2006) Mol. Cell. Biol ; 26: 4149 - 4160.Nadia Dub |
Specification |
|
|---|---|
| Aliases | DOK1 |
| Entrez GeneID | 1796; |
| Swissprot | Q99704 |
| WB Predicted band size | 62kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 398 (E-G-Y(p)-E-L) derived from Human p62Dok. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from K562 cells untreated or treated with H2O2 using p62Dok(phospho-Tyr398) Antibody P40254.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p62Dok(Phospho-Tyr398) Antibody P40254(left) or the same antibody preincubated with blocking peptide(right).
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