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Mouse Monoclonal Antibody to DFFA
货号: 31719
别名: DFF1; ICAD; DFF-45
应用: FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: O00273
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Description

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

References

1.Nat Commun. 2017 Nov 9;8(1):1392.
2.Cell Rep. 2017 May 2;19(5):1022-1032.

Specification

Aliases DFF1; ICAD; DFF-45
Entrez GeneID 1676
Swissprot O00273
clone 2B10C8
WB Predicted band size 36.5kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human DFFA (AA: 179-331) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

FCM 1/200 - 1/400
ELISA 1/10000
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