Rabbit Polyclonal Antibody to TrkA(Phospho-Tyr791)

科研抗体 IVD抗体

货号： P40294

别名： High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth factor receptor; TRK; TRK1 transforming tyrosine kinase protein

应用： WB,IF

反应种属： Human,Mouse,Rat

抗体类型： Primary antibody

Swissprot： P04629

规格：

100μl 50μl

目录价

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Description
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Description

References
Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17210-5. Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12270-5 Inoue K, et al. J Biol Chem. 2007 Aug 17;282(33):24175-84

Specification
Aliases	High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth factor receptor; TRK; TRK1 transforming tyrosine kinase protein
Entrez GeneID	4914;
Swissprot	P04629
WB Predicted band size	140kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D) derived from Human TrkA.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000
IF	1/100-1/200