Rabbit Polyclonal Antibody to ABL1/2 (phospho-Tyr393/439)
货号：
P40317
别名：
Abelson murine leukemia viral oncogene homolog 1; c-ABL; p150
应用：
WB,IHC,IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P00519
规格：
目录价
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Description |
|---|
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. |
References |
|---|
| Wang, J.Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N.N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B.B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259. |
Specification |
|
|---|---|
| Aliases | Abelson murine leukemia viral oncogene homolog 1; c-ABL; p150 |
| Entrez GeneID | 25; |
| Swissprot | P00519 |
| WB Predicted band size | 210kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 393/439 (D-T-Y(p)-T-A) derived from Human ABL1/2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/200 |
Product Image
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Western blot analysis of extracts from HL60 cells using ABL1/2(phospho-Tyr393/439) Antibody P40317 and the same antibody preincubated with blocking peptide.
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Immunofluorescence staining of methanol-fixed Hela cells using ABL1/2(phospho-Tyr393/439) Antibody P40317.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ABL1/2(Phospho-Tyr393/439) Antibody P40317(left) or the same antibody preincubated with blocking peptide(right).
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