Rabbit Polyclonal Antibody to Arrestin 1 (Phospho-Ser412)
货号：
P40374
别名：
ARR1; arrestin 2; arrestin beta 1; beta-arrestin-1;
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P49407
规格：
目录价
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Description |
|---|
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. Greg Buchanan. AACR Meeting Abstracts, Apr 2006; 2006: 430. D. Alex Groarke. Mol. Pharmacol., Feb 2001; 59: 375. Karen McConalogue. Mol. Biol. Cell, Aug 1998; 9: 2305. Maria Stella Lombardi. Stroke, Apr 2004; 35: 981 - 986 |
Specification |
|
|---|---|
| Aliases | ARR1; arrestin 2; arrestin beta 1; beta-arrestin-1; |
| Entrez GeneID | 408; |
| Swissprot | P49407 |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of Serine 412 (T-G-S(p)-P-Q) derived from Human Arrestin 1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from COS7 cells treated with Etoposide using Arrestin 1 (Phospho-Ser412) Antibody P40374.The lane on the right is treated with the antigen-specific peptide.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Arrestin 1 (Phospho-Ser412) antibody P40374 (left)or the same antibody preincubated with blocking peptide (right).
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