Rabbit Polyclonal Antibody to Ras-GRF1 (Phospho-Ser916)
货号：
P40391
别名：
CDC25; GNRP; GRF1; RASGRF1;
应用：
IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q13972
规格：
目录价
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Description |
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Ras activity is regulated by GAP (GTPase activating proteins) and GEFs (guanine nucleotide exchange factors). Ras-GRF1 (also known as CDC25Mm) is neuronal RasGEF and is regulated by heterotrimeric G proteins and calcium influx . Binding to calmodulin and phosphorylation stimulate Ras-GRF1 activity. Multiple PKA phosphorylation sites on Ras-GRF have been identified. Phosphorylation on the two major sites, Ser54 and Ser822, inhibits Ras-GRF activity. Carbachol (a muscarinic agonist)-induced phosphorylation on Ser916 is essential but not sufficient for maximal Ras-GRF activity |
References |
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| Huibin Yang, J. Biol. Chem., Apr 2003; 278: 13278 - 13285. Huibin Yang, Mol. Biol. Cell, May 2006; 17: 2177 - 2189. Raymond R. Mattingly, J. Biol. Chem., Dec 1999; 274: 37379. Tie-Nian Zhu, J. Biol. Chem., May 2007; 282: 14816 - 14826. |
Specification |
|
|---|---|
| Aliases | CDC25; GNRP; GRF1; RASGRF1; |
| Entrez GeneID | 5923; |
| Swissprot | Q13972 |
| WB Predicted band size | 145kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of Serine 916(R-M-S(p)-L-A) derived from Mouse Ras-GRF1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| IHC | 1/50-1/100 |
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