Rabbit Polyclonal Antibody to Caspase 9 (Phospho-Thr125)
货号：
P40371
别名：
APAF-3; MCH6; RNCASP9; CASP-9; ICE-LAP6
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P55211
规格：
目录价
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Description |
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Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. |
References |
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| Duan H., J. Biol. Chem. 271:16720-16724(1996)Srinivasula S.M., J. Biol. Chem. 271:27099-27106(1996)Hadano S., Mamm. Genome 10:757-760(1999) |
Specification |
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|---|---|
| Aliases | APAF-3; MCH6; RNCASP9; CASP-9; ICE-LAP6 |
| Entrez GeneID | 842; |
| Swissprot | P55211 |
| WB Predicted band size | 47kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of threonine 125 (P-E-T(p)-P-R) derived from Human Caspase 9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from HeLa cells treated with TNF using Caspase 9 (Phospho-Thr125) Antibody P40371.The lane on the right is treated with the antigen-specific peptide.
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Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Caspase 9 (Phospho-Thr125) antibody P40371 (left)or the same antibody preincubated with blocking peptide (right).
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