Rabbit Polyclonal Antibody to Pim-1 (Phospho-Tyr309)
货号：
P40390
别名：
PIM-1; Proto-oncogene serine/threonine-protein kinase pim-1; EC 2.7.11.1;
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P11309
规格：
目录价
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Description |
|---|
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. |
References |
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| Selten G., Cell 46:603-611(1986) Saris C.J., EMBO J. 10:655-664(1991) Maita H., Eur. J. Biochem. 267:5168-5178(2000). |
Specification |
|
|---|---|
| Aliases | PIM-1; Proto-oncogene serine/threonine-protein kinase pim-1; EC 2.7.11.1; |
| Entrez GeneID | 5292; |
| Swissprot | P11309 |
| WB Predicted band size | 45kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 309(H-R-Y(p)-H-G) derived from Human Pim-1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
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