Rabbit Polyclonal Antibody to Amyloid β A4 (Phospho-Thr743/668)
货号:
P40365
别名:
A4; AD1; APP; APPI; Beta-amyloid protein 42
应用:
WB,IHC,IF
反应种属:
Human,Mouse,Rat
抗体类型:
Primary antibody
Swissprot:
P05067
规格:
目录价
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Description |
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Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Ming-Sum Lee J. Cell Biol., Oct 2003; 163: 83Tadashi Nakaya and Toshiharu Suzuki Genes Cells, Jun 2006; 11: 633 - 645Keun-A Chang, Mol. Cell. Biol., Jun 2006; 26: 4327 篓C 4338Thor D. Stein J. Neurosci., Sep 2004; 24: 7707 - 7717 |
Specification |
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Aliases | A4; AD1; APP; APPI; Beta-amyloid protein 42 |
Entrez GeneID | 351; |
Swissprot | P05067 |
WB Predicted band size | 140kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | Peptide sequence around phosphorylation site of threonine743 /668 (A-V-T(p)-P-E) derived from Human Amyloid β A4. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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WB | 1/500-1/1000 |
IHC | 1/50-1/100 |
IF | 1/100-1/200 |
Product Image
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Western blot analysis of extracts from cos-7 cells (Lane 2), using Amyloid β A4 (Phospho-Thr743/668) Antibody P40365. The lane on the left is treated with antigen-specific peptide.
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Immunofluorescence staining of methanol-fixed HeLa cells using Amyloid β A4 (phospho-Thr743/668) Antibody P40365.
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Immunohistochemical analysis of paraffin-embedded human brain tissue using Amyloid β; A4 (phospho-Thr743/668) antibody P40365 (left)or the same antibody preincubated with blocking peptide (right).