Rabbit Polyclonal Antibody to p9RSK (Phospho-Thr573)
货号：
P40381
别名：
KS6A1; p90RSK1; RSK1; RPS6KA1;
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q15418
规格：
目录价
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Description |
|---|
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206. Ye Zhang, J. Biol. Chem., May 2002; 277: 19042 - 19048. Ganesh R. Panta, Mol. Cell. Biol., Mar 2004; 24: 1823 - 1835. |
Specification |
|
|---|---|
| Aliases | KS6A1; p90RSK1; RSK1; RPS6KA1; |
| Entrez GeneID | 6195; |
| Swissprot | Q15418 |
| WB Predicted band size | 95kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of threonine 573(L-M-T(p)-P-C) derived from Human p90 RSK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from 293 cells treated with UV using p90 RSK (Phospho-Thr573) Antibody P40381.The lane on the right is treated with the antigen-specific peptide.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p90 RSK (Phospho-Thr573) antibody P40381 (left)or the same antibody preincubated with blocking peptide (right).
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