Rabbit Polyclonal Antibody to BAD (Phospho-Ser91/128)
货号：
P40397
别名：
BAD; BBC6; BCL2L8; Bcl- XL/Bcl-2 associated death promoter;
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q92934
规格：
目录价
在线咨询
Description |
|---|
The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform |
References |
|---|
| Wang H.-G., Cell 87:629-638(1996) Ottilie S., J. Biol. Chem. 272:30866-30872(1997) The MGC Project Team, Genome Res. 14:2121-2127(2004). |
Specification |
|
|---|---|
| Aliases | BAD; BBC6; BCL2L8; Bcl- XL/Bcl-2 associated death promoter; |
| Entrez GeneID | 572; |
| Swissprot | Q92934 |
| WB Predicted band size | 22kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of Serine 128 (E-L-S(p)-P-F) derived from Mouse BAD. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
-
Western blot analysis of extracts from COS7 cells treated with TNF-a using BAD (Phospho-Ser91/128) Antibody P40397.The lane on the right is treated with the antigen-specific peptide.
-
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BAD (Phospho-Ser91/128) antibody P40397 (left)or the same antibody preincubated with blocking peptide (right).
鄂公网安备42018502007531号
