Rabbit Polyclonal Antibody to BLK (Phospho-Tyr501)
货号：
P40431
别名：
p55-BLK; EC 2.7.10.2; kinase Blk; B lymphocyte kinase; Tyrosine-protein kinase BLK
应用：
IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P51451
规格：
目录价
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Description |
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Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Islam K.B., J. Immunol. 154:1265-1272(1995)Drebin J.A.,Oncogene 10:477-486(1995)Greenman C.,Nature 446:153-158(2007). |
Specification |
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|---|---|
| Aliases | p55-BLK; EC 2.7.10.2; kinase Blk; B lymphocyte kinase; Tyrosine-protein kinase BLK |
| Entrez GeneID | 640; |
| Swissprot | P51451 |
| WB Predicted band size | 57kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 501 (R-Q-Y(p)-E-L) derived from Human BLK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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| IHC | 1/50-1/100 |
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