Rabbit Polyclonal Antibody to ALK (Phospho-Tyr1096)
货号：
P40430
别名：
ALK tyrosine kinase receptor; anaplastic lymphoma kinase; anaplastic lymphoma kinase (Ki-1); CD246; EC 2.7.10.1; kinase ALK
应用：
IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q9UM73
规格：
目录价
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Description |
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The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. Morris S.W., Oncogene 14:2175-2188(1997)Morris S.W., Oncogene 15:2883-2883(1997)Iwahara T., Oncogene 14:439-449(1997). |
Specification |
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|---|---|
| Aliases | ALK tyrosine kinase receptor; anaplastic lymphoma kinase; anaplastic lymphoma kinase (Ki-1); CD246; EC 2.7.10.1; kinase ALK |
| Entrez GeneID | 238; |
| Swissprot | Q9UM73 |
| WB Predicted band size | 176kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 1096 (P-N-Y(p)-C-F) derived from Human ALK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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|---|---|
| IHC | 1/50-1/100 |
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