Rabbit Polyclonal Antibody to IGF2R (Phospho-Ser2409)
货号：
P40416
别名：
CI-MPR; CI-MPR; MPR300; MPRI;
应用：
WB,IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P11717
规格：
目录价
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Description |
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Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.Morgan D.O., Nature 329:301-307(1987)Oshima A., J. Biol. Chem. 263:2553-2562(1988)Killian J.K., Mamm. Genome 10:74-77(1999) |
Specification |
|
|---|---|
| Aliases | CI-MPR; CI-MPR; MPR300; MPRI; |
| Entrez GeneID | 3482; |
| Swissprot | P11717 |
| WB Predicted band size | 300kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of Serine 2409(Q-D-S(p)-E-D) derived from Human IGF2R. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from COS-7 cells treated with UV using IGF2R (Phospho-Ser2409) Antibody P40416.The lane on the right is treated with the antigen-specific peptide.
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Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF2R (Phospho-Ser2409) antibody P40416 (left)or the same antibody preincubated with blocking peptide (right).
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