Rabbit Polyclonal Antibody to FADD (Phospho-Ser191)
货号：
P40519
别名：
MORT1 ; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity;
应用：
WB,IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q61160
规格：
目录价
在线咨询
Description |
|---|
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development |
References |
|---|
| Sugano S., Nat. Genet. 36:40-45(2004) Farmer A., Submitted (MAY-2003) Venter J.C., Submitted (JUL-2005). |
Specification |
|
|---|---|
| Aliases | MORT1 ; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; |
| Entrez GeneID | 14082; |
| Swissprot | Q61160 |
| WB Predicted band size | 25kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of Serine191(N-M-S(p)-P-V) derived from Mouse FADD. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
-
Western blot analysis of extracts from Jurkat cells treated with PMA using FADD (Phospho-Ser191) Antibody P40519.The lane on the right is treated with the antigen-specific peptide.
-
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using FADD (Phospho-Ser191) antibody P40519 (left)or the same antibody preincubated with blocking peptide (right).
鄂公网安备42018502007531号
