Rabbit Polyclonal Antibody to Pin1 (Phospho-Ser16)
货号：
P40595
别名：
PPIase Pin1; Rotamase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; EC 5.2.1.8;
应用：
WB
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q13526
规格：
目录价
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Description |
|---|
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.Lee YC, et al. (2013)J Cell Sci 126, 4862-72. Ando K, et al. (2013)Neurobiol Aging 34, 757-69. Nechama M, Lin CL, Richter JD (2013)Mol Cell Biol 33, 48-58. |
Specification |
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|---|---|
| Aliases | PPIase Pin1; Rotamase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; EC 5.2.1.8; |
| Entrez GeneID | 5300; |
| Swissprot | Q13526 |
| WB Predicted band size | 18kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of serine16(R-M-S(p)-R-S) derived from Human Pin1 . |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
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