Rabbit Polyclonal Antibody to BRCA2 (Phospho-Ser3291)
货号：
P40539
别名：
BRCC2; BRCA2; subunit 2; BRCA1/BRCA2-containing complex;
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P51587
规格：
目录价
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Description |
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Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. Wooster R., Nature 378:789-792(1995)Tavtigian S.V., Nat. Genet. 12:333-337(1996)Dunham A., Nature 428:522-528(2004) |
Specification |
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|---|---|
| Aliases | BRCC2; BRCA2; subunit 2; BRCA1/BRCA2-containing complex; |
| Entrez GeneID | 675; |
| Swissprot | P51587 |
| WB Predicted band size | >350kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of Serine 3291 (F-V-S(p)-P-A) derived from Human BRCA2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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|---|---|
| WB | 1/500-1/1000 |
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