Rabbit Polyclonal Antibody to MDM4 (Phospho-Ser367)
货号：
P40746
别名：
double minute 4 protein; Mdm2-like p53-binding protein; MDMX; p53-binding protein Mdm4
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
O15151
规格：
目录价
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Description |
|---|
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. |
Specification |
|
|---|---|
| Aliases | double minute 4 protein; Mdm2-like p53-binding protein; MDMX; p53-binding protein Mdm4 |
| Entrez GeneID | 4194; |
| Swissprot | O15151 |
| WB Predicted band size | 80kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of serine 367 (T-I-S(p)-A-P) derived from Human MDM4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from HeLa cells, treated with calyculinA (50ng/ml, 30mins), using MDM4 (Phospho-Ser367) antibody P40746. The lane on the right is treated with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using MDM4 (Phospho-Ser367) antibody P40746. The picture on the right is treated with the synthesized peptide.
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