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Rabbit Polyclonal Antibody to GSK3b(Ab-9)
货号: P41239
别名: Factor A, GSK-3 beta, Protein kinase GSK-3-beta, kinase GSK-3 beta,
应用: WB,IHC,IF
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: P49841
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Description

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

References

Fan G, et al. (2003) J Biol Chem. 278(52): 52432-52436. Barry FA, et al. (2003) FEBS Lett. 553(1-2): 173-178. Welsh, et al. (1996) Trends Cell Biol. 6: 274-279. Srivastava A K, et al. (1998) Mol Cell Biochem. 182: 135-141. Cross D. A, et al. (1995) Nature. 378: 785-789.

Specification

Aliases Factor A, GSK-3 beta, Protein kinase GSK-3-beta, kinase GSK-3 beta,
Entrez GeneID 2932;
Swissprot P49841
WB Predicted band size 46kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa.7~11 (T-T-S-F-A) derived from Human GSK3b.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
IF 1/100-1/200
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