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Rabbit Polyclonal Antibody to PKR (Phospho-Thr446)
货号: P41235
别名: Double stranded RNA activated protein kinase; antibody</br> E2AK2_HUMAN antibody</br> eIF-2A protein kinase 2 antibody</br> EIF2AK1 antibody</br> EIF2AK2 antibody</br> Eukaryotic translation initiation factor 2 alpha kinase 2 antibody</br> Eukaryotic tran
应用: WB,IP,IHC
反应种属: Human, Mouse, Rat
抗体类型: Primary antibody
Swissprot: P19525
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Description

An interferon-inducible, RNA-dependent protein serine/threonine kinase, PKR has various designations. Mouse PKR is known as DAI, dsJ, PI kinase, p65, p67 or TIK, whereas human PKR is known as p68 or p69. PKR phosphorylates its substrate, a subunit of protein synthesis initiation factor eIF-2 on Ser 51 to inhibit translation. PKR contains two dsRNA binding motifs required for its activation by dsRNA. Three kinds of regulation of PKR enzymatic activity occur, and these include transcriptional regulation in response to interferon, an autoregulatory mechanism controlling PKR expression at the level of translation, and posttranslational regulation by RNA mediated autophosphorylation. Human PKR contains at least 15 autophosphorylation sites, but only Thr-446 and Thr-451 in the activation loop are critical for its kinase activity. Thr-446 is the in vivo autophosphorylation site of PKR. Mutation of threonine to alanine at position 446 substantially reduces PKR function, and mutant kinase containing Ala-451 is completely inactive.

Specification

Aliases Double stranded RNA activated protein kinase; antibody
E2AK2_HUMAN antibody
eIF-2A protein kinase 2 antibody
EIF2AK1 antibody
EIF2AK2 antibody
Eukaryotic translation initiation factor 2 alpha kinase 2 antibody
Eukaryotic translation initiation factor 2-alpha kinase 2 antibody
HGNC:9437 antibody
Interferon induced double stranded RNA activated protein kinase antibody
Interferon inducible elF2 alpha kinase antibody
Interferon inducible RNA dependent protein kinase antibody
Interferon-induced, double-stranded RNA-activated protein kinase antibody
Interferon-inducible RNA-dependent protein kinase antibody
MGC126524 antibody
P1/eIF-2A protein kinase antibody
P1/eIF2A protein kinase antibody
p68 kinase antibody
PKR antibody
PPP1R83 antibody
PRKR antibody
Protein kinase interferon inducible double stranded RNA dependent antibody
Protein kinase RNA activated antibody
Protein kinase RNA-activated antibody
Protein phosphatase 1 regulatory subunit 83 antibody
Serine/threonine protein kinase TIK antibody
Tyrosine protein kinase EIF2AK2 antibody
Entrez GeneID 5610;
Swissprot P19525
WB Predicted band size 68kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Mouse, Rat
Immunogen Amino acid sequence containing phosphorylated Thr 446 of PKR of human origin.
Formulation Purified antibody in TBS with 0.05% sodium azide,1%BSA and 50% glycerol.

Application

WB 1/1000-1/1000
IP IP1-2 μg per100-500 μg of total protein (1 ml of cell lysate)
IHC 1/50-500
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