Mouse Monoclonal Antibody to FAK (Phospho-Ser 722)
货号:
P41232
别名:
FADK 1 antibody</br> FADK antibody</br> FAK related non kinase polypeptide antibody</br> FAK1 antibody</br> FAK1_HUMAN antibody</br> Focal adhesion kinase 1 antibody</br> Focal adhesion Kinase antibody</br> Focal adhesion kinase isoform FAK Del33 antibody
应用:
WB,IP,IHC
反应种属:
Human, Mouse, Rat
抗体类型:
Primary antibody
Swissprot:
Q05397
规格:
目录价
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Description |
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Activation of integrins in the extracellular matrix (ECM) of eukaryotic cells promotes the formation of membrane adhesion complexes, known as focal adhesions, which can include cytoskeletal proteins and protein tyrosine kinases, such as focal adhesion kinase (FAK). Phosphorylation events occurring within focal adhesions influence numerous processes that include mitogenic signaling, cell survival and cell motility. FAK is a non-receptor tyrosine kinase that is ubiquitously expressed and highly conserved between species. FAK is recruited by integrin clusters and variably phosphorylated depending on the effector molecules present in the focal adhesion. Phospho-rylation of FAK Tyr 397 decreases during serum starvation, contact inhibition and cell cycle arrest, all conditions under which activating FAK Tyr 407 phosphorylation increases. |
Specification |
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Aliases | FADK 1 antibody FADK antibody FAK related non kinase polypeptide antibody FAK1 antibody FAK1_HUMAN antibody Focal adhesion kinase 1 antibody Focal adhesion Kinase antibody Focal adhesion kinase isoform FAK Del33 antibody Focal adhesion kinase related nonkinase antibody FRNK antibody p125FAK antibody pp125FAK antibody PPP1R71 antibody Protein phosphatase 1 regulatory subunit 71 antibody Protein tyrosine kinase 2 antibody Protein-tyrosine kinase 2 antibody Ptk2 antibody PTK2 protein tyrosine kinase 2 antibody |
Entrez GeneID | 5747; |
Swissprot | Q05397 |
WB Predicted band size | 125kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | peptide |
Formulation | Purified antibody in TBS with 0.05% sodium azide,1%BSA and 50% glycerol. |
Application |
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WB | 1/1000-1/1000 |
IP | IP/1-2μper100-500μg of total protein(1 ml of cell lysate) |
IHC | 1/50-1/500 |
Product Image
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A.Western blot analysis of FAK phosphorylation in non-transfected:(A,D), untreated human FAK transfected:(B,E) and lambda protein phosphatase treated human FAK transfected:(C,F) 293T whole cell lysates. Antibodies tested include p-FAK (A-12):(A,B,C) and FAK (C-903):(D,E,F).
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B.Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of glandular cells.