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Mouse Monoclonal Antibody to FAK (Phospho-Ser 722)
货号: P41232
别名: FADK 1 antibody</br> FADK antibody</br> FAK related non kinase polypeptide antibody</br> FAK1 antibody</br> FAK1_HUMAN antibody</br> Focal adhesion kinase 1 antibody</br> Focal adhesion Kinase antibody</br> Focal adhesion kinase isoform FAK Del33 antibody
应用: WB,IP,IHC
反应种属: Human, Mouse, Rat
抗体类型: Primary antibody
Swissprot: Q05397
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Description

Activation of integrins in the extracellular matrix (ECM) of eukaryotic cells promotes the formation of membrane adhesion complexes, known as focal adhesions, which can include cytoskeletal proteins and protein tyrosine kinases, such as focal adhesion kinase (FAK). Phosphorylation events occurring within focal adhesions influence numerous processes that include mitogenic signaling, cell survival and cell motility. FAK is a non-receptor tyrosine kinase that is ubiquitously expressed and highly conserved between species. FAK is recruited by integrin clusters and variably phosphorylated depending on the effector molecules present in the focal adhesion. Phospho-rylation of FAK Tyr 397 decreases during serum starvation, contact inhibition and cell cycle arrest, all conditions under which activating FAK Tyr 407 phosphorylation increases.

Specification

Aliases FADK 1 antibody
FADK antibody
FAK related non kinase polypeptide antibody
FAK1 antibody
FAK1_HUMAN antibody
Focal adhesion kinase 1 antibody
Focal adhesion Kinase antibody
Focal adhesion kinase isoform FAK Del33 antibody
Focal adhesion kinase related nonkinase antibody
FRNK antibody
p125FAK antibody
pp125FAK antibody
PPP1R71 antibody
Protein phosphatase 1 regulatory subunit 71 antibody
Protein tyrosine kinase 2 antibody
Protein-tyrosine kinase 2 antibody
Ptk2 antibody
PTK2 protein tyrosine kinase 2 antibody
Entrez GeneID 5747;
Swissprot Q05397
WB Predicted band size 125kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Mouse, Rat
Immunogen peptide
Formulation Purified antibody in TBS with 0.05% sodium azide,1%BSA and 50% glycerol.

Application

WB 1/1000-1/1000
IP IP/1-2μper100-500μg of total protein(1 ml of cell lysate)
IHC 1/50-1/500
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