产品中心
PRODUCT CENTER
首页 »产品中心 »抗体 »科研抗体 »
Rabbit Polyclonal Antibody to Myc(Ab-358)
货号: P41267
别名: c-myc
应用: WB,IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: P01106
规格:
目录价
在线咨询

Description

Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. The expression correlates with the proliferation state of the cells. Transcription is repressed in quiescent or terminally differentiated cells. Expression of Myc is generally induced after mitogenic stimulation of cells or serum induction. Myc therefore is an important positive regulator of cell growth and proliferation. Myc has been demonstrated also to be a potent inducer of apoptosis when expressed in the absence of serum or growth factors. Apoptosis may serve also as a protective mechanism to prevent tumorigenicity elicited by deregulated Myc expression. Sequences of the Myc oncogene have been highly conserved throughout evolution, from Drosophila to vertebrates

References

Baudino T A, et al. (2001) Mol Cell Biol. 21: 691-702.Blackwood E M, et al. (1991) Science. 251:1211-1217.Henriksson M, et al. (1996) Adv Cancer Res. 68: 109-182.Grandori C, et al. (2000) Annu Rev Cell Dev Biol. 16: 653-699.

Specification

Aliases c-myc
Entrez GeneID 4609;
Swissprot P01106
WB Predicted band size 60kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Peptide sequence around aa.356~360 (R-R-T-H-N) derived from Human Myc.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
联系我们
  • 电话:17771420241 18911818852
  • 联系人:刘经理
  • 地址:湖北省武汉市东湖新技术开发区高新大道666号光谷生物城C6栋C6403、C6404
微信公众号
版权所有 © 武汉博开生物科技有限公司  备案编号:鄂ICP备2024052832号-1鄂公网安备42018502007531号
17771420241 18911818852