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Rabbit Polyclonal Antibody to MEF2a(Ab-312)
货号: P41269
别名: MEF2; Serum response factor-like protein 1;
应用: WB,IHC
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: Q02078
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Description

The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain

References

Kato Y, et al. (2000) J Biol Chem. 275(24): 18534-18540.Zhao M, et al. (1999) Mol Cell Biol. 19(1): 21-30.

Specification

Aliases MEF2; Serum response factor-like protein 1;
Entrez GeneID 4205;
Swissprot Q02078
WB Predicted band size 54kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa.310~314 (L-A-T-P-V) derived from Human MEF2A.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
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