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Rabbit Polyclonal Antibody to BAD(Ab-136)
货号: P41291
别名: Bbc2
应用: WB,IHC
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: Q61337
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Description

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

References

Wang XQ, et al. (2001). J Biol Chem.276 (48): 44504-44511. Lee YI, et al. (2001). J Biol Chem.276 (20): 16969-16977. Maiti D, et al. (2001). J Biol Chem.276 (1): 329-333.

Specification

Aliases Bbc2
Entrez GeneID 12015;
Swissprot Q61337
WB Predicted band size 23kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa.134~138 (S-R-S-A-P) derived from Mouse BAD.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
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