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Rabbit Polyclonal Antibody to p95/NBS1(Ab-343)
货号: P41286
别名: NBN
应用: WB,IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: O60934
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Description

Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

References

Hsu HL, et al (2005)Oncogene; 24(31): 4956-64.Falck J, et al. (2005) Nature; 434(7033): 605-11.Buscemi G, et al. (2004) Oncogene; 23(46): 7691-700.Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A; 101(33): 12130-5.

Specification

Aliases NBN
Entrez GeneID 4683;
Swissprot O60934
WB Predicted band size 95kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Peptide sequence around aa.341~345 (S-L-S-Q-G) derived from Human p95/NBS1.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
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