Rabbit Polyclonal Antibody to p95/NBS1(Ab-343)
货号：
P41286
别名：
NBN
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
O60934
规格：
目录价
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Description |
|---|
Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. |
References |
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| Hsu HL, et al (2005)Oncogene; 24(31): 4956-64.Falck J, et al. (2005) Nature; 434(7033): 605-11.Buscemi G, et al. (2004) Oncogene; 23(46): 7691-700.Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A; 101(33): 12130-5. |
Specification |
|
|---|---|
| Aliases | NBN |
| Entrez GeneID | 4683; |
| Swissprot | O60934 |
| WB Predicted band size | 95kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.341~345 (S-L-S-Q-G) derived from Human p95/NBS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from Jurkat cells using p95/NBS1(Ab-343) Antibody P41286 and the same antibody preincubated with blocking peptide.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p95/NBS1(Ab-343) Antibody P41286(left) or the same antibody preincubated with blocking peptide(right).
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