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Rabbit Polyclonal Antibody to p53(Ab-15)
货号: P41312
别名: Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13; TP53;
应用: WB,IHC,IF
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: P04637
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Description

p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes

References

Lin T, et al. (2005) Nat Cell Biol; 7(2): 165-71. Vega FM, et al. (2004) Mol Cell Biol; 24(23): 10366-80. Li J, et al. (2004) J Biol Chem; 279(40): 41275-9. Wang J, et al. (2004) J Biol Chem; 279(38): 39584-92.

Specification

Aliases Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13; TP53;
Entrez GeneID 7157;
Swissprot P04637
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa.13~17 (P-L-S-Q-E) derived from Human p53.
Formulation Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

Application

WB 1/500-1/2000
IHC 1/100-1/300
IF 1/200-1/1000

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