Rabbit Polyclonal Antibody to Integrin b3(Ab-773)
货号:
P41309
别名:
Platelet membrane glycoprotein IIIa
应用:
WB,IHC
反应种属:
Human,Mouse,Rat
抗体类型:
Primary antibody
Swissprot:
P05106
规格:
目录价
在线咨询
Description |
---|
Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
References |
---|
Chandhoke SK, et al. |
Specification |
|
---|---|
Aliases | Platelet membrane glycoprotein IIIa |
Entrez GeneID | 3690; |
Swissprot | P05106 |
WB Predicted band size | 110kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | Peptide sequence around aa. 771~775 (P-L-Y-K-E) derived from Human Integrin b3. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
---|---|
WB | 1/500-1/1000 |
IHC | 1/50-1/100 |