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Rabbit Polyclonal Antibody to Caveolin-1(Ab-14)
货号: P41333
别名: CAV; CAV1;
应用: WB
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: Q03135
规格:
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Description

The scaffolding protein encoded by Caveolin-1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (a and beta) are encoded by a single transcript from this gene.

References

Zhang Y, et al. (2005) Mol Cell Proteomics. 4(9): 1240-1250.Labrecque L, et al. (2004) J Biol Chem. 279(50): 52132-52140.Fielding PE, et al. (2004) Biochemistry. 43(9): 2578-2586.Labrecque L, et al. (2003) Mol Biol Cell. 14(1): 334-347.Maggi D, et al. (2002) Biochem Biophys Res Commun. 295(5): 1085-1089.

Specification

Aliases CAV; CAV1;
Entrez GeneID 857;
Swissprot Q03135
WB Predicted band size 24kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa.12~16 (H-L-Y-T-V) derived from Human CAVEOLIN-1.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
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