Rabbit Polyclonal Antibody to FKHR(Ab-256)
货号：
P41354
别名：
FOXO1
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q12778
规格：
目录价
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Description |
|---|
FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14 |
References |
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| Gan L, et al. (2005) J Neurochem; 93(5): 1209-19. Smith WW, et al. (2005) J Cell Biol; 169(2): 331-9. Di Maira G, et al. (2005) Cell Death Differ; 12(6): 668-77. Horn S, et al. (2004) Leukemia; 18(11): 1839-49. Zhao X, et al. (2004) Biochem J 4; 378(Pt 3): 839-49. |
Specification |
|
|---|---|
| Aliases | FOXO1 |
| Entrez GeneID | 2308; |
| Swissprot | Q12778 |
| WB Predicted band size | 78-82 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.254~258 (A-A-S-M-D) derived from Human FKHR/FOXO1A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/200 |
Product Image
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Western blot analysis of extracts from Hela cells using FKHR(Ab-256) Antibody P41354.
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Immunofluorescence staining of methanol-fixed Hela cells using FKHR(Ab-256) Antibody P41354.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FKHR(Ab-256) Antibody P41354(left) or the same antibody preincubated with blocking peptide(right).
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