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Rabbit Polyclonal Antibody to HDAC4(Ab-632)
货号: P41357
别名: HD4; Histone deacetylase 4;
应用: WB,IF
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: P56524
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Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

References

Wang AH, et al. (2000) Mol Cell Biol. 20(18): 6904-6912. Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97(14): 7835-7840.

Specification

Aliases HD4; Histone deacetylase 4;
Entrez GeneID 9759;
Swissprot P56524
WB Predicted band size 140kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa. 630~634 (A-Q-S-S-P) derived from Human HDAC4.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IF 1/100-1/200
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