Rabbit Polyclonal Antibody to PAK1/PAK2/PAK3(Ab-423/402/421)
货号：
P41379
别名：
p21-activated kinase 1; PAK-1; p65-PAK; Alpha-PAK;
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q13153
规格：
目录价
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Description |
|---|
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. |
References |
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| Parsons M, et al. (2005) Mol Cell Biol ; 25:1680-1695.Jung JH, et al. (2005) J Biol Chem; 280:40025-40031.Lampugnani MG, et al. (2002) Mol Biol Cell ; 13: 1175-1189Wang RA, et al. (2002) EMBO J; 21: 5437 - 5447. |
Specification |
|
|---|---|
| Aliases | p21-activated kinase 1; PAK-1; p65-PAK; Alpha-PAK; |
| Entrez GeneID | 5058; |
| Swissprot | Q13153 |
| WB Predicted band size | 61-67 (PAK2) 68-74 (PAK1/3)kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.421~425/400~404/419~423 (R-S-T-M-V) derived from Human PAK1/PAK2/PAK3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/200 |
Product Image
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Western blot analysis of extracts from MCF-7 and Hela cells using PAK1/PAK2/PAK3(Ab-423/402/421) Antibody P41379.
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Immunofluorescence staining of methanol-fixed Hela cells using PAK1/PAK2/PAK3(Ab-423/402/421) Antibody P41379.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PAK1/PAK2/PAK3(Ab-423/402/421) Antibody P41379(left) or the same antibody preincubated with blocking peptide(right).
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