产品中心
PRODUCT CENTER
首页 »产品中心 »抗体 »科研抗体 »
Rabbit Polyclonal Antibody to PAK1/PAK2/PAK3(Ab-423/402/421)
货号: P41379
别名: p21-activated kinase 1; PAK-1; p65-PAK; Alpha-PAK;
应用: WB,IHC,IF
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: Q13153
规格:
目录价
在线咨询

Description

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

References

Parsons M, et al. (2005) Mol Cell Biol ; 25:1680-1695.Jung JH, et al. (2005) J Biol Chem; 280:40025-40031.Lampugnani MG, et al. (2002) Mol Biol Cell ; 13: 1175-1189Wang RA, et al. (2002) EMBO J; 21: 5437 - 5447.

Specification

Aliases p21-activated kinase 1; PAK-1; p65-PAK; Alpha-PAK;
Entrez GeneID 5058;
Swissprot Q13153
WB Predicted band size 61-67 (PAK2) 68-74 (PAK1/3)kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa.421~425/400~404/419~423 (R-S-T-M-V) derived from Human PAK1/PAK2/PAK3.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
IF 1/100-1/200
联系我们
  • 电话:17771420241 18911818852
  • 联系人:刘经理
  • 地址:湖北省武汉市东湖新技术开发区高新大道666号光谷生物城C6栋C6403、C6404
微信公众号
版权所有 © 武汉博开生物科技有限公司  备案编号:鄂ICP备2024052832号-1鄂公网安备42018502007531号
17771420241 18911818852