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Rabbit Polyclonal Antibody to FAK(Ab-925)
货号: P41362
别名: FADK 1; FAK1; PTK2
应用: WB,IHC,IF
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: Q05397
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Description

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

References

Sanders MA, et al. (2005) J Biol Chem; 280(25): 23516-22.Cherubini A, et al. (2005) Mol Biol Cell; 16(6): 2972-83.Toriumi Y, et al. (2003) FEBS Lett; 553(3): 419-22.Shi Q, et al. (2003) Mol Biol Cell; 14(10): 4306-15.

Specification

Aliases FADK 1; FAK1; PTK2
Entrez GeneID 5747;
Swissprot Q05397
WB Predicted band size 125kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa.923~927 (K-V-Y-E-N) derived from Human FAK.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
IF 1/100-1/200
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