Rabbit Polyclonal Antibody to FAK(Ab-925)
货号：
P41362
别名：
FADK 1; FAK1; PTK2
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q05397
规格：
目录价
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Description |
|---|
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. |
References |
|---|
| Sanders MA, et al. (2005) J Biol Chem; 280(25): 23516-22.Cherubini A, et al. (2005) Mol Biol Cell; 16(6): 2972-83.Toriumi Y, et al. (2003) FEBS Lett; 553(3): 419-22.Shi Q, et al. (2003) Mol Biol Cell; 14(10): 4306-15. |
Specification |
|
|---|---|
| Aliases | FADK 1; FAK1; PTK2 |
| Entrez GeneID | 5747; |
| Swissprot | Q05397 |
| WB Predicted band size | 125kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.923~927 (K-V-Y-E-N) derived from Human FAK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/200 |
Product Image
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Western blot analysis of extracts from Hela cells using FAK(Ab-925) Antibody P41362 and the same antibody preincubated with blocking peptide.
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Immunofluorescence staining of methanol-fixed Hela cells using FAK(Ab-925) Antibody P41362.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FAK(Ab-925) Antibody P41362(left) or the same antibody preincubated with blocking peptide(right).
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