Rabbit Polyclonal Antibody to ATM(Ab-1981)
货号:
P41361
别名:
Ataxia telangiectasia mutated homolog; Ataxia telangiectasia mutated; kinase ATM
应用:
WB,IF
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
Q13315
规格:
目录价
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Description |
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ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. |
References |
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Gupta A. et al. (2005) Mol Cell Biol. 25(12): 5292-5305.Bernstein JL. et al. (2002) Breast Cancer Res. 4(6): 249-252.Silverman J. et al. (2004) Genes Dev. 18(17): 2108-2119.Nakada D. et al. (2003) Nucleic Acids Res. 31(6): 1715-1724. |
Specification |
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Aliases | Ataxia telangiectasia mutated homolog; Ataxia telangiectasia mutated; kinase ATM |
Entrez GeneID | 472; |
Swissprot | Q13315 |
WB Predicted band size | 350kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Peptide sequence around aa.1979~1983 (E-G-S-Q-S) derived from Human ATM. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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WB | 1/500-1/1000 |
IF | 1/100-1/200 |