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Rabbit Polyclonal Antibody to ATM(Ab-1981)
货号: P41361
别名: Ataxia telangiectasia mutated homolog; Ataxia telangiectasia mutated; kinase ATM
应用: WB,IF
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q13315
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Description

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.

References

Gupta A. et al. (2005) Mol Cell Biol. 25(12): 5292-5305.Bernstein JL. et al. (2002) Breast Cancer Res. 4(6): 249-252.Silverman J. et al. (2004) Genes Dev. 18(17): 2108-2119.Nakada D. et al. (2003) Nucleic Acids Res. 31(6): 1715-1724.

Specification

Aliases Ataxia telangiectasia mutated homolog; Ataxia telangiectasia mutated; kinase ATM
Entrez GeneID 472;
Swissprot Q13315
WB Predicted band size 350kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Peptide sequence around aa.1979~1983 (E-G-S-Q-S) derived from Human ATM.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IF 1/100-1/200
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