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Rabbit Polyclonal Antibody to SMC1(Ab-957)
货号: P41396
别名: SM1A; SMC1A; SMC1L1; SMC1 alpha protein;
应用: WB,IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q14683
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Description

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

References

Yang XM. et al. (2004) Mol Cell Biol. 24(12): 5290-5303.Kim ST. et al. (2002) Genes Dev. 16(5): 560-570.Revenkova E.et al. (2001) Mol Cell Biol. 21(20): 6984-6998

Specification

Aliases SM1A; SMC1A; SMC1L1; SMC1 alpha protein;
Entrez GeneID 8243;
Swissprot Q14683
WB Predicted band size 145kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Peptide sequence around aa. 955~959 (G-S-S-Q-G) derived from Human SMC1.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
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