Rabbit Polyclonal Antibody to MSK1(Ab-376)
货号：
P41402
别名：
MSPK1; RPS6KA5;
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
O75582
规格：
目录价
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Description |
|---|
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). |
References |
|---|
| Roux PP, et al. (2004) Microbiol Mol Biol Rev. Jun; 68(2): 320-344McCOY C, et al. (2005) Biochem J. Apr 15; 387(Pt 2): 507-517 |
Specification |
|
|---|---|
| Aliases | MSPK1; RPS6KA5; |
| Entrez GeneID | 9252; |
| Swissprot | O75582 |
| WB Predicted band size | 90kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.374~378 (G-Y-S-F-V) derived from Human MSK1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
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