Rabbit Polyclonal Antibody to Merlin(Ab-518)
货号：
P41453
别名：
MERL; NF2; Neurofibromin 2; SCH; Schwannomerlin
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P35240
规格：
目录价
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Description |
|---|
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. |
References |
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| Guang-Hui Xiao, et al. (2005) Mol. Cell. Biol ; 25: 2384 - 2394. Hi-Su Yang, et al. (2006) Cancer Res ; 66: 2708 - 2715. R Bohni, et al. (1994) J. Biol. Chem ; 269: 14541 - 14545. Adam J. Ratner, et al. (2001) J. Biol. Chem ; 276: 19267 - 19275. |
Specification |
|
|---|---|
| Aliases | MERL; NF2; Neurofibromin 2; SCH; Schwannomerlin |
| Entrez GeneID | 4771; |
| Swissprot | P35240 |
| WB Predicted band size | 69kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.516~520 (R-L-S-M-E) derived from Human Merlin. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
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