Rabbit Polyclonal Antibody to BRCA1(Ab-1423)
货号：
P41433
别名：
RNF53
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P38398
规格：
目录价
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Description |
|---|
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation |
References |
|---|
| Kim ST, et al. (2002) Genes Dev; 16(5): 560-570 Arlt MF, et al. (2004) Mol Cell Biol; 24(15): 6701-6709 Zhang J, et al. (2004) Mol Cell Biol; 24(2): 708-718 Greenberg RA, et al. (2006) Genes Dev; 20(1): 34-46 Tibbetts RS, et al. (2000) Genes Dev; 14(23): 2989-3002 |
Specification |
|
|---|---|
| Aliases | RNF53 |
| Entrez GeneID | 672; |
| Swissprot | P38398 |
| WB Predicted band size | 220kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.1421~1425 (H-G-S-Q-P) derived from Human BRCA1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
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