Rabbit Polyclonal Antibody to Pyk2(Ab-402)
货号：
P41413
别名：
FADK 2; FAK2; Focal adhesion kinase 2; PTK2B; Proline-rich tyrosine kinase 2 RAFTK
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q14289
规格：
目录价
在线咨询
Description |
|---|
Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation. |
References |
|---|
| Gluck SL, et al. (2004) J Clin Invest; 114(12): 1696-1699Benzing T, et al. (2001) Proc Natl Acad Sci U S A; 98(17): 9784-9789Tian D, et al. (2002) Mol Cell Biol; 22(8): 2650-2662Lu Z, et al. (2001) Mol Cell Biol; 21(12): 4016-4031Krishnan HH, et al. (2006) J Virol; 80(3): 1167-1180 |
Specification |
|
|---|---|
| Aliases | FADK 2; FAK2; Focal adhesion kinase 2; PTK2B; Proline-rich tyrosine kinase 2 RAFTK |
| Entrez GeneID | 2185; |
| Swissprot | Q14289 |
| WB Predicted band size | 140kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.400~404 (D-I-Y-A-E) derived from Human Pyk2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/200 |
Product Image
-
Western blot analysis of extracts from 293 cells using Pyk2(Ab-402) Antibody P41413.
-
Immunofluorescence staining of methanol-fixed Hela cells using Pyk2(Ab-402) Antibody P41413.
-
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Pyk2(Ab-402) Antibody P41413(left) or the same antibody preincubated with blocking peptide(right).
鄂公网安备42018502007531号
