Rabbit Polyclonal Antibody to PKR(Ab-446)
货号：
P41464
别名：
ADRB2; E2AK2; EIF2AK2; EIF2aK; PRKR
应用：
WB,IHC,IF
反应种属：
Human,Rat
抗体类型：
Primary antibody
Swissprot：
P19525
规格：
目录价
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Description |
|---|
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. |
References |
|---|
| Abujiang Pataer, et,al. (2002) Cancer Res ; 62: 2239.K. D. Ryman, et,al. (2005) J. Virol ; 79: 1487 - 1499.Susana Guerra, et,al. (2006) J. Biol. Chem ; 281: 18734 - 18745. |
Specification |
|
|---|---|
| Aliases | ADRB2; E2AK2; EIF2AK2; EIF2aK; PRKR |
| Entrez GeneID | 5610; |
| Swissprot | P19525 |
| WB Predicted band size | 68kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Peptide sequence around aa.444~448 (K-R-T-R-S) derived from Human PKR. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/200 |
Product Image
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Western blot analysis of extracts from 293, Hela and C6 cells using PKR(Ab-446) Antibody P41464.
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Immunofluorescence staining of methanol-fixed Hela cells using PKR(Ab-446) Antibody P41464.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PKR(Ab-446) Antibody P41464(left) or the same antibody preincubated with blocking peptide(right).
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