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Rabbit Polyclonal Antibody to p62Dok(Ab-398)
货号: P41462
别名: DOK1
应用: WB,IHC,IF
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q99704
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Description

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

References

Michael J. Wick,et,al. (2001) J. Biol. Chem; 276: 42843 - 42850.Paul D. Simoncic, et,al. (2006) Mol. Cell. Biol; 26: 4149 - 4160.Nadia Dub

Specification

Aliases DOK1
Entrez GeneID 1796;
Swissprot Q99704
WB Predicted band size 62kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Peptide sequence around aa.396~400 (P-I-Y-D-E) derived from Human p62Dok.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
IF 1/100-1/200
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