Rabbit Polyclonal Antibody to Keratin 8(Ab-74)
货号：
P41493
别名：
CK 8; CK8; CYK8; Cytokeratin endo A; K8
应用：
WB,IHC,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P05787
规格：
目录价
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Description |
|---|
Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. |
References |
|---|
| Nakamichi I, et al. (2002) Mol Biol Cell; 13(10): 3441-3451.Prochasson P, et al. (2002) Nucleic Acids Res; 30(15): 3312-3322.Pankov R, et al. (1994) Proc Natl Acad Sci U S A; 91(3): 873-877.Thorey IS, et al. (1993) Mol Cell Biol; 13(11): 6742-6751. |
Specification |
|
|---|---|
| Aliases | CK 8; CK8; CYK8; Cytokeratin endo A; K8 |
| Entrez GeneID | 3856; |
| Swissprot | P05787 |
| WB Predicted band size | 55kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.72~76 (L-L-S-P-L) derived from Human Keratin 8 (CK8). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/200 |
Product Image
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Western blot analysis of extracts from HUVEC and 293 cells using Keratin 8(Ab-74) Antibody P41493.
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Immunofluorescence staining of methanol-fixed Hela cells using Keratin 8(Ab-74) Antibody P41493.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Keratin 8(Ab-74) Antibody P41493(left) or the same antibody preincubated with blocking peptide(right).
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