Rabbit Polyclonal Antibody to PKCth(Ab-676)
货号：
P41480
别名：
nPKC-theta
应用：
WB,IHC,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q04759
规格：
目录价
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Description |
|---|
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol. which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. |
References |
|---|
| Kristof Van Kolen, et al. (2006) FEBS J ; 273: 1843 - 1854.Martin Villalba, et al. (2002) J. Cell Biol ; 157: 253. Jie Zhang, et al. (2004) J. Biol. Chem ; 279: 22118 - 22123. Castro AF, et al. (1998) Am J Physiol Cell Physiol; 275: C113 - C119. |
Specification |
|
|---|---|
| Aliases | nPKC-theta |
| Entrez GeneID | 5588; |
| Swissprot | Q04759 |
| WB Predicted band size | 80kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa. 674~678 (R-L-S-F-A) derived from Human PKCth. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/200 |
Product Image
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Western blot analysis of extracts from PC12 cells using PKCth(Ab-676) Antibody P41480.
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Immunofluorescence staining of methanol-fixed Hela cells using PKCth(Ab-676) Antibody P41480.
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Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PKCth(Ab-676) Antibody P41480(left) or the same antibody preincubated with blocking peptide(right).
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