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Rabbit Polyclonal Antibody to Caspase 9
货号: P41524
别名: ICE-like apoptotic protease 6
应用: WB
反应种属: Human
抗体类型: Primary antibody
Swissprot: P55211
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Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

References

Zou, H. et al. (1999) J. Biol. Chem. 274, 11549-11556.Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223.Li, P. et al. (1997) Cell 91, 479-489.

Specification

Aliases ICE-like apoptotic protease 6
Entrez GeneID 842;
Swissprot P55211
WB Predicted band size 47 37 35kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
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