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Rabbit Polyclonal Antibody to STAT2(Ab-690)
货号: P41556
别名: P113; ISGF-3; STAT113
应用: WB,IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: P52630
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Description

STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus.

References

Fu, X. et al. (1992) Biochemistry 89, 7840-7843.Park, C. et al. (2000) Immunity 13, 795-804.Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964.Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780.

Specification

Aliases P113; ISGF-3; STAT113
Entrez GeneID 6773;
Swissprot P52630
WB Predicted band size 113kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
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