Rabbit Polyclonal Antibody to STAT2(Ab-690)
货号：
P41556
别名：
P113; ISGF-3; STAT113
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P52630
规格：
目录价
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Description |
|---|
STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. |
References |
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| Fu, X. et al. (1992) Biochemistry 89, 7840-7843.Park, C. et al. (2000) Immunity 13, 795-804.Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964.Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780. |
Specification |
|
|---|---|
| Aliases | P113; ISGF-3; STAT113 |
| Entrez GeneID | 6773; |
| Swissprot | P52630 |
| WB Predicted band size | 113kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from Hela cells using STAT2(Ab-690) Antibody P41556 and the same antibody preincubated with blocking peptide.
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Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2(Ab-690) Antibody P41556(left) or the same antibody preincubated with blocking peptide(right).
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