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Rabbit Polyclonal Antibody to c-Cbl(Ab-700)
货号: P41567
别名: Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55;
应用: WB,IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: P22681
规格:
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Description

Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

References

Blake, T.J. et al. (1991) Oncogene 6, 653-657.Thien, C.B. and Langdon, W.Y. (1998) Immunol. Cell Biol. 76, 473-482.Kamei, T. et al. (2000) Int. J. Oncol. 17, 335-339.Hunter, C. et al. (1999) J. Biol. Chem. 274, 2097-2106.

Specification

Aliases Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55;
Entrez GeneID 867;
Swissprot P22681
WB Predicted band size 120kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Peptide sequence around aa. 698~702 (T-E-Y-M-T) derived from Human c-Cbl.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
IHC 1/50-1/100
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