Rabbit Polyclonal Antibody to c-Cbl(Ab-700)
货号:
P41567
别名:
Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55;
应用:
WB,IHC
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
P22681
规格:
目录价
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Description |
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Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling. |
References |
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Blake, T.J. et al. (1991) Oncogene 6, 653-657.Thien, C.B. and Langdon, W.Y. (1998) Immunol. Cell Biol. 76, 473-482.Kamei, T. et al. (2000) Int. J. Oncol. 17, 335-339.Hunter, C. et al. (1999) J. Biol. Chem. 274, 2097-2106. |
Specification |
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Aliases | Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55; |
Entrez GeneID | 867; |
Swissprot | P22681 |
WB Predicted band size | 120kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Peptide sequence around aa. 698~702 (T-E-Y-M-T) derived from Human c-Cbl. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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WB | 1/500-1/1000 |
IHC | 1/50-1/100 |