Rabbit Polyclonal Antibody to FAK(Ab-576/577)
货号:
P41563
别名:
FADK 1; FAK1; PTK2
应用:
WB,IHC
反应种属:
Human,Mouse,Rat
抗体类型:
Primary antibody
Swissprot:
Q05397
规格:
目录价
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Description |
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Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. |
References |
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Parsons, J.T. et al. (2000) Oncogene 19, 5606-5613.Schaller, M.D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688.Chen, H.C. et al. (1996) J. Biol. Chem. 271, 26329-26334.Calalb, M.B. et al. (1995) Mol. Cell. Biol. 15, 954-963. |
Specification |
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Aliases | FADK 1; FAK1; PTK2 |
Entrez GeneID | 5747; |
Swissprot | Q05397 |
WB Predicted band size | 125kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | Peptide sequence around aa.574~578/575~579 (T-Y-Y-K-A) derived from Human FAK. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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WB | 1/500-1/1000 |
IHC | 1/50-1/100 |