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Rabbit Polyclonal Antibody to Tau
货号: P41574
别名: MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
应用: WB
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: P19332
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Description

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

References

Johnson , G.V. and Stoothoff , W.H. (2004) J. Cell Sci. 117, 5721-5729. Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476. Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.

Specification

Aliases MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
Swissprot P19332
WB Predicted band size 48 62 78kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa. 725-729(T-G-S-I-D) derived from Rat Tau
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
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