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Rabbit Polyclonal Antibody to NMDANR2B Subunit
货号: P41572
别名: NMDAR2B; NR2B;
应用: WB
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: Q00960
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Description

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death

References

Kornau H.C., Schenker L.T., Kennedy M.B., Seeburg P.H.Science 269:1737-1740(1995) Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.Mol. Cell. Neurosci. 11:161-172(1998)

Specification

Aliases NMDAR2B; NR2B;
Entrez GeneID 24410;
Swissprot Q00960
WB Predicted band size 180kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa.1250-1254(N-L-Y-D-I) derived from Human NMDANR2B Subunit.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/1000
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